If you fill a R4XX as a gas, the component with the lowest boiling point will boil out of the liquid and thus the amount of this component charged will be larger! If you are going to empty the entire cilinder of gas it doens't matter if you fill liquid or gas, because all is comming out anyway.

But if you charge just say 3 of 12 kg as gas, the lower boiling component will be larger in mass then in the original mixture!