EN378-2008 Refrigerant Practical Limits In Plantrooms

[Gibbo]

Would appreciate any comments or help regarding the above regulation first saw it mentioned on the IOR website and subsequently on a GEA guide to refrigeration plantrooms.
It mentions about refrigerant practical limits relating to refrigerant charge versus plantroom size in regard to water cooled chillers it mentions refrigerants such as R123, Ammonia R134A, R410A etc.R123 and ammonia I was aware of the needs for R123 and Ammonia but I had never heard it mention for the other refrigerants in plantrooms.
Anybody familar with EN378-2008 or have a copy with the section on plantrooms, is it a legal requirement or not.

I am aware that there has always been practical limits for occupied hotel rooms etc in the case of VRF etc to prevent asphxyation.

Thanks Guys

Gibbo